Showing posts with label Inline process refractometers. Show all posts
Showing posts with label Inline process refractometers. Show all posts

Inline Process Refractometers Used in Vaccine and Drug Development

Process Refractometer for Vaccine Development


Inline process refractometers are used in drug development and in vaccine manufacturing to ensure safety and efficacy. Their use is integral to the development of virus-based vaccines for diseases such as influenza, MERS, SARS, and COVID-19.

Process refractometers determine the concentration of dissolved solids by making real-time optical measurements of the refractive index (RI) and temperature in a solution. In-process Refractive Index monitoring improves the understanding of process conditions, reduces pharmaceutical development time, increases production capacity, improves product stability and product quality, as well as assisting in regulation compliance. RI measurement and control data supports the pharmaceutical manufacturer's  process validation throughout the drug or vaccine development cycle.

Inline process refractometers with hygienic or sanitary process connections are specially designed for the pharmaceutical industry and are used for the measurement of dissolved components in liquids. Sucrose density in virus purification is one example. Viruses can be banded in density gradients of sucrose, and the purification of viruses is done via sucrose density gradient centrifugation. Measuring the sucrose density with process refractometers allows for safe, accurate and efficient collection, ultimately assisting in speedier vaccine development.

For more information on the use and implementation of inline process refractometers for drug and vaccine development, contact Electron Machine Corporation. Call the in the USA at +1 352-669-3101 of visit their web site at https://electronmachine.com.